【作者单位】1 Department of Genetics, Stanford University, Stanford University School of Medicine, Stanford, MA, 94305-5120 2 Lewis-Sigler Institute for Integrative Genomics, Princeton University, Carl Icahn Lab Room 134, Washington Road, Princeton, NJ, 08544
【出 处】Federation of American Societies for Experimental Biology Journal
【摘 要】 The Saccharomyces Genome Database (SGD; http://www.yeastgenome.org) collects and organizes biological information about the genes, proteins, and chromosomal features of S. cerevisiae, and presents this information on Locus Summary pages for every fea... 更多 >> The Saccharomyces Genome Database (SGD; http://www.yeastgenome.org) collects and organizes biological information about the genes, proteins, and chromosomal features of S. cerevisiae, and presents this information on Locus Summary pages for every feature. Locus Summary pages contain such information as descriptions of the function and role of the feature, mutant phenotype data, summaries of physical and genetic interaction data, and results of large-scale gene expression studies. Through this extensive annotation SGD has become a powerful resource for studies of related proteins in other organisms. SGD has developed web-based tools that integrate searching among these diverse types of data to discover functional connections among sets of genes. These tools, such as the GO Term Finder, allow for analysis of gene list results from high-throughput assays to identify, cellular localizations or biological roles that a set of proteins shares in common. Use of comparison resources such as the Model Organism BLASTP Best Hits identifies proteins in other organisms that may be orthologs to those identified in the assay. Examples describing the use of these tools will be discussed. The SGD project is an ongoing effort and we welcome feedback from users. SGD is funded as a National Genomic Resource by the National Human Genome Research Institute at the National Institutes of Health. << 收起
